Journal
BIOMATERIALS
Volume 53, Issue -, Pages 107-116Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2015.02.072
Keywords
Nanoparticles; Oxidative stress; Lamin B1; TRF proteins; Telomere length; Adaptive response
Funding
- Polish Ministry of Science and Higher Education within the Operational Program - Innovative Economy [19/POIG/GP/2013]
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In general, nanoparticle-based materials are promising candidates for use in biological systems for diagnostic and therapeutic approaches. However, these materials' actions at the molecular level remain poorly understood. Nanoparticle (silica, silver and diamond)-induced oxidative stress and activation of the NF-kappa B pathway lead to the depletion of lamin B1 pools, which, in turn, results in upregulation of telomeric repeat binding factor (TRF) protein expression and maintenance of telomere length. In cancer cells, the TRF-based response is independent of the p53 pathway. In fibroblasts with active p53/p21 signaling, the levels of p53 and p21 are elevated and stress-induced premature senescence is observed. These results suggest that nanoparticles promote a telomere-focused cell adaptive response. (C) 2015 Elsevier Ltd. All rights reserved.
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