Journal
BIOLOGICAL PSYCHIATRY
Volume 87, Issue 1, Pages 34-43Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2019.05.025
Keywords
Astroglia; Extracellular matrix; Opioid; Plasticity; Postsynapse; Presynapse
Categories
Funding
- National Institutes of Health [DA007288, DA044782, DA046143, DA003906, DA012513]
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Opioid administration in preclinical models induces long-lasting adaptations in reward and habit circuitry. The latest research demonstrates that in the nucleus accumbens, opioid-induced excitatory synaptic plasticity involves presynaptic and postsynaptic elements as well as adjacent astroglial processes and the perisynaptic extracellular matrix. We outline opioid-induced modifications within each component of the tetrapartite synapse and provide a neurobiological perspective on how these adaptations converge to produce addiction-related behaviors in rodent models. By incorporating changes observed at each of the excitatory synaptic compartments into a unified framework of opioid-induced glutamate dysregulation, we highlight new avenues for restoring synaptic homeostasis that might limit opioid craving and relapse vulnerability.
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