Journal
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume 42, Issue 6, Pages 954-959Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.b18-00967
Keywords
apoptosis; collagen type I; collagen type III; dextran sodium sulfate-induced ulcerative colitis; hydrogen peroxide; vitamin C
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Funding
- Japan Society for the Promotion of Science (JSPS) [18K06802]
- Grants-in-Aid for Scientific Research [18K06802] Funding Source: KAKEN
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Vitamin C is a natural nutrient with antioxidant properties and is used as a health supplement. In this study, we examined the effects of intraperitoneal administration of high-dose vitamin C (4g/kg) on dextran sodium sulfate (DSS)-induced ulcerative colitis. We prepared a mouse ulcerative colitis model by administering DSS for 7d along with high-dose vitamin C each day during DSS treatment. Ulcerative colitis induced by DSS was ameliorated by high-dose vitamin C administration. Blood levels of interleukin-6, tumor necrosis factor-alpha, hydrogen peroxide (H2O2), and iron were elevated in DSS-treated mice but lowered by high-dose vitamin C administration. Contrarily, the levels of H2O2 and iron and the numbers of terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling (TUNEL)-positive cells in the colon were further increased by high-dose vitamin C administration. The expression levels of fibroblasts, collagen type I, and collagen type III decreased in the DSS-treated mice but increased in mice administered high-dose vitamin C. These results suggest that high-dose vitamin C administration can improve ulcerative colitis.
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