Journal
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume 42, Issue 7, Pages 1134-1139Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.b18-01002
Keywords
cinnamic acid; caffeic acid phenethyl ester; breast cancer; prostate cancer; apoptosis
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Funding
- Hoshi University
- JSPS KAKENHI [JP17K15485]
- JSPS Core-to-Core Program, A. Advanced Research Networks, Japan
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Cancer is the leading cause of death and there is a particularly pressing need to develop effective treatments for breast and prostate cancer. In the current study, we show the inhibitory effects of cinnamic acid derivatives, including caffeic acid phenethyl ester (CAPE, 1), on the growth of breast and prostate cancer cells. Among the compounds examined, 3,4,5-trihydroxycinnamic acid decyl ester (6) showed the most potent inhibition of cancer cell growth by the induction of apoptosis. Compound 6 could be a new anti-cancer agent for use against breast and prostate cancer.
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