Journal
BIOINFORMATICS
Volume 35, Issue 24, Pages 5391-5392Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btz570
Keywords
-
Categories
Funding
- European Union's Horizon 2020 program [681002]
- Novo Nordisk Foundation [NNF14CC0001]
- University of Paris Descartes-USPC
- university of Paris Diderot
- INSERM
Ask authors/readers for more resources
Motivation: Adverse outcome pathway (AOP) is a toxicological concept proposed to provide a mechanistic representation of biological perturbation over different layers of biological organization. Although AOPs are by definition chemical-agnostic, many chemical stressors can putatively interfere with one or several AOPs and such information would be relevant for regulatory decision-making. Results: With the recent development of AOPs networks aiming to facilitate the identification of interactions among AOPs, we developed a stressor-AOP network (sAOP). Using the 'cytotoxitiy burst' (CTB) approach, we mapped bioactive compounds from the ToxCast data to a list of AOPs reported in AOP-Wiki database. With this analysis, a variety of relevant connections between chemicals and AOP components can be identified suggesting multiple effects not observed in the simplified 'one-biological perturbation to one-adverse outcome' model. The results may assist in the prioritization of chemicals to assess risk-based evaluations in the context of human health.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available