Journal
BIOESSAYS
Volume 41, Issue 9, Pages -Publisher
WILEY
DOI: 10.1002/bies.201900048
Keywords
CCCTC-binding factor (CTCF); chromatin; cohesin; Drosophila; insulators; loop domains; topologically associated domains
Categories
Funding
- Biotechnology and Biological Sciences Research Council [BB/M007081/1]
- Engineering and Physical Sciences Research Council [EP/M506436/1, EP/M507969/1, EP/N509565/1]
- BBSRC [BB/M007081/1] Funding Source: UKRI
- EPSRC [1885346] Funding Source: UKRI
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The organization of the genome into topologically associated domains (TADs) appears to be a fundamental process occurring across a wide range of eukaryote organisms, and it likely plays an important role in providing an architectural foundation for gene regulation. Initial studies emphasized the remarkable parallels between TAD organization in organisms as diverse as Drosophila and mammals. However, whereas CCCTC-binding factor (CTCF)/cohesin loop extrusion is emerging as a key mechanism for the formation of mammalian topological domains, the genome organization in Drosophila appears to depend primarily on the partitioning of chromatin state domains. Recent work suggesting a fundamental conserved role of chromatin state in building domain architecture is discussed and insights into genome organization from recent studies in Drosophila are considered.
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