Journal
BIOCHEMICAL PHARMACOLOGY
Volume 167, Issue -, Pages 107-115Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bcp.2019.06.012
Keywords
PARP; Cancer stem cells; PARP inhibitors
Categories
Funding
- Ligue Nationale Contre le Cancer (LNCC), Ligue Contre Le Cancer Grand Est-Bourgogne-Franche Comte (CCIR-Grand Est), Universite de Strasbourg, Region Grand Est, CNRS
- [LABEX ANR-10-LABX0034_Medalis]
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Cancer stem cells (CSCs) are of fundamental importance in tumor progression because of their tumor-initiating properties, their resistance to radio- and chemotherapy, their invasive properties and their propensity to escape immune responses that together contribute to tumor relapse. These highly aggressive features underscore the importance of constantly identifying new and innovative therapeutic solutions to eradicate these cells. In this narrative review we discuss recent findings on the involvement of PARP family members in cancer stem cell biology and the benefit of their inhibition. Nonetheless, an important limitation in the use of PARP inhibitors is the emergence of a prominent function of PARP1 in non-cancer stem cell biology including stem cell maintenance and differentiation during development, neurogenesis or adipogenesis. Thus, we also summarize the dominant discoveries revealing the importance of PARP1 in normal stem cell biology.
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