Journal
AUTOPHAGY
Volume 15, Issue 10, Pages 1854-1856Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15548627.2019.1645545
Keywords
Autophagy; circadian rhythm; gene oscillation; REV-ERB alpha; TFEB; TFE3
Categories
Funding
- US National Institutes of Health [R01-NS078072]
- AIRC (Italian Association for Cancer Research) [IG 2015-17639]
- Foundation Louis-Jeantet
- Telethon Foundation
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Most essential physiological functions in mammals show a 24-h rhythmic pattern, which includes sleep-wake, feeding-non-feeding cycles and energy metabolism. Recent studies indicate that macroautophagy/autophagy also displays a robust circadian rhythmicity following the daily feeding pattern in adult mammals. We discovered that MiT-TFE transcription factors TFEB and TFE3, master regulators of autophagy and lysosomal biogenesis, are activated in a circadian manner and drive the expression of NR1D1/REV-ERB alpha, a key component of the core clockwork, thus revealing a molecular link between the nutrient-driven circadian cycle and the light-induced molecular clock. The dynamic balance between TFEB and TFE3 activation and NR1D1 expression is responsible for the modulation and oscillation of autophagy and metabolism genes.
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