Journal
AUTOPHAGY
Volume 15, Issue 10, Pages 1677-1681Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15548627.2019.1646540
Keywords
Autophagy; lysosome; macroautophagy; selective autophagy; stress
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Funding
- National Institute of General Medical Sciences [GM131919]
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The endoplasmic reticulum (ER) is the main site of cellular protein and calcium homeostasis, as well as lipid synthesis in eukaryotic cells. Reticulophagy is the selective clearance and degradation of ER components and membranes by the cellular autophagy machinery. Recently, 2 groups (the laboratories of Noboru Mizushima and Wade Harper) independently identified the previously uncharacterized protein TEX264 (testis expressed gene 264) as a major receptor for selective reticulophagy in mammalian cells. Here we highlight and integrate the major findings of their recent work.
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