Journal
AUTOPHAGY
Volume 16, Issue 1, Pages 18-27Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15548627.2019.1628543
Keywords
Autophagy; embryogenesis; gametogenesis; resource allocation; sexual reproduction
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Funding
- National Natural Science Foundation of China [91649202]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA16020701]
- National Key R&D Program of China [2016YFA0500901]
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Sexual reproduction is the most common form of reproduction among eukaryotes, which is characterized by a series of massive cellular or tissue renovations. Recent studies have revealed novel functions of autophagy during sexual reproductive processes, ranging from yeast to mammals. In mammals, autophagy is indispensable for spermatogenesis and oogenesis, and it participates in early embryonic development and maternal-fetus crosstalk to ensure the development of embryos or fetuses. Thus, autophagy provides the molecular basis for resource allocation among parents and their offspring, providing an important way to benefit the next generation.
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