Journal
BIOMATERIALS
Volume 41, Issue -, Pages 89-96Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2014.11.031
Keywords
CBD-BDNF; Linear ordered collagen scaffold (LOCS); Canine; Spinal cord injury (SCI); Regeneration
Funding
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA01030401]
- National High Technology Research and Development Program (863 Program) of China [2012AA020501]
- National Natural Science Foundation of China [30930032]
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Spinal cord injury (SCI) is still a worldwide clinical challenge for which there is no viable therapeutic method. We focused on developing combinatorial methods targeting the complex pathological process of SCI. In this study, we implanted linear-ordered collagen scaffold (LOCS) fibers with collagen binding brain-derived neurotrophic factor (BDNF) by tagging a collagen-binding domain (CBD) (LOCS + CBD-BDNF) in completely transected canine SCI with multisystem rehabilitation to validate its potential therapeutic effect through a long-term (38 weeks) observation. We found that LOCS + CBD-BDNF implants strikingly promoted locomotion and functional sensory recovery, with some dogs standing unassisted and transiently moving. Further histological analysis showed that administration of LOCS + CBD-BDNF reduced lesion volume, decreased collagen deposits, promoted axon regeneration and improved myelination, leading to functional recovery. Collectively, LOCS + CBD-BDNF showed striking therapeutic effect on completely transected canine SCI model and it is the first time to report such breakthrough in the war with SCI. Undoubtedly, it is a potentially promising therapeutic method for SCI paralysis or other movement disorders caused by neurological diseases in the future. (C) 2014 Elsevier Ltd. All rights reserved.
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