Journal
BIOMATERIALS
Volume 73, Issue -, Pages 214-230Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2015.09.018
Keywords
Physical stimulus; Theranostics; Cancer therapies
Funding
- National Basic Research Programs of China (973 Program) [2012CB932600, 2011CB911002]
- National Natural Science Foundation of China [51222203, 51132006]
- Juangsu Natural Science Fund for Distinguished Young Scholars [BK20130005]
- Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions
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Physical stimulus-responsive therapies often employing multifunctional theranostic agents responsive to external physical stimuli such as light, magnetic field, ultra-sound, radiofrequency, X-ray, etc., have been widely explored as novel cancer therapy strategies, showing encouraging results in many pre-clinical animal experiments. Unlike conventional cancer chemotherapy which often accompanies with severe toxic side effects, physical stimulus-responsive agents usually are non-toxic by themselves and would destruct cancer cells only under specific external stimuli, and thus could offer greatly reduced toxicity and enhanced treatment specificity. In addition, physical stimulus-responsive therapies can also be combined with other traditional therapeutics to achieve synergistic anti-tumor effects via a variety of mechanisms. In this review, we will summarize the latest progress in the development of physical stimulus-responsive therapies, and discuss the important roles of nanoscale theranostic agents involved in those non-conventional therapeutic strategies. (C) 2015 Elsevier Ltd. All rights reserved.
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