Journal
BIOMATERIALS
Volume 71, Issue -, Pages 132-144Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2015.08.023
Keywords
Surgical mesh; Polypropylene; Plasma; Drug delivery; Surface modification; Fibroblast
Funding
- L'Oreal-Unesco programme for Women in Science, the Spanish Government
- Generalitat de Catalunya [SGR 2014-1075, SGR 2014-1333]
- Slovenian Research Agency (ARRS)
- European Commission [MP1101]
Ask authors/readers for more resources
Hernia repair is one of the most common operations in general surgery, and its associated complications typically relate to infections, among others. The loading of antibiotics to surgical meshes to deliver them locally in the abdominal hernia repair site can be one way to manage infections associated with surgical implants. However, the amount of drug loaded is restricted by the low wettability of polypropylene (PP). In this work, plasma has been used to tailor the surface properties of PP meshes to obtain high loading of ampicillin while conserving the desired biological properties of the unmodified samples and conferring them with antibacterial activity. It was demonstrated that the new surface chemistry and improved wettability led to 3-fold higher antibiotic loading. Subsequently, a PEG-like dry coating was deposited from tetraglyme with low-pressure plasma which allowed maintaining the high drug loading and kept cell properties such as chemotaxis, adhesion and morphology to the same levels as the untreated ones which have shown long-standing clinical success. (C) 2015 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available