PVA/alginate/hydroxyapatite films for controlled release of amoxicillin for the treatment of periodontal defects

Periodontal diseases are treated currently treated with antibiotics. Polymer based drug delivery is less effective and the patient needs bone grafting in the infected areas as there will be a periodontal loss. Hydroxyapatite (HAp) is a biocompatible materials used for various bone infections and periodontal regeneration. In our present work Hydroxyapatite (HAp) nanoparticles incorporated in polyvinyl alcohol-sodium alginate (PVA-SA) films were developed and used as a bone substitute for treating infrabony periodontal defects. Fabricated particles and patches were characterized by XRD, FTIR, TEM. Polymeric films were analysis for hemolysis, swelling study, drug realizes and antibacterial assay. Amoxicillin is used as the antibiotic drug. Amoxicillin is added to the HAP/polymer blend and the drug release was studied. Amoxicillin helps in healing the infection while HAP NPs helps in periodontal regeneration.