Journal
BIOMATERIALS
Volume 73, Issue -, Pages 142-148Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2015.09.023
Keywords
Photoacoustic imaging; Optoacoustic; Organic nanoparticles; Naphthalocyanines; Sentinel lymph node mapping
Funding
- NIPA IT Consilience Creative Program [NIPA-2013-H0203-13-1001]
- NRF Engineering Research Center [NRF-2011-0030075]
- Marine Biotechnology Program [20150220]
- China-ROK [NRF-2013K1A3A1A20046921]
- National Institutes of Health [DP5OD017898]
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Demarking lymph node networks is important for cancer staging in clinical practice. Here, we demonstrate in vivo dual-color photoacoustic lymphangiography using all-organic nanoformulated naphthalocyanines (referred to as nanonaps). Nanonap frozen micelles were self-assembled from two different naphthalocyanine dyes with near-infrared absorption at 707 nm or 860 nm. These allowed for noninvasive, nonionizing, high resolution photoacoustic identification of separate lymphatic drainage systems in vivo. With both types of nanonaps, rat lymph nodes buried deeply below an exogenously-placed 10 mm thick layer of chicken breast were clearly visualized in vivo. These results show the potential of multispectral photoacoustic imaging with nanonaps for detailed mapping of lymphatic drainage systems. (C) 2015 Elsevier Ltd. All rights reserved.
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