Journal
APPLIED RADIATION AND ISOTOPES
Volume 153, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2019.108826
Keywords
Ho-166; Activity standardization; gamma-spectrometry; Half-life measurements; Molecular radiotherapy; MRTDosimetry project
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Funding
- European Metrology Programme for Innovation and Research (EMPIR) joint research project from the European Union [15HLT06]
- European Union's Horizon 2020 research and innovation programme
- EMPIR Participating States
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Holmium-166 is a high-energy beta(-)-emitter radionuclide (similar to 1.8 MeV) with a short half-life (similar to 26.8h) that offers great potential as an alternative to Y-90 for the treatment of liver cancer based on radioembolization. The possibility of quantitative Single Photon Emission Computed Tomography (SPECT) imaging of the main gamma-ray emission at 80.6 keV, in addition to strong paramagnetic properties suitable for Magnetic Resonance Imaging (MRI), complement this therapeutic potential. The present paper describes the measurements carried out in three European radionuclide metrology laboratories for primary standardization of Ho-166 and new determinations of X- and gamma-ray photon-emission intensities in the framework of the European EMPIR project MRTDosimetry. New half-life measurements were also performed.
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