Journal
APPLIED MECHANICS REVIEWS
Volume 71, Issue 4, Pages -Publisher
ASME
DOI: 10.1115/1.4043947
Keywords
cell micro-environment; mechanobiology; mechanotransduction; cell volume
Categories
Funding
- National Natural Science Foundation of China [11522219, 11532009]
- New Faculty Foundation of NUAA [1001-YAH19016]
- Foundation of Jiangsu Provincial Key Laboratory of Bionic Functional Materials [1001-XCA1816310]
- Foundation for the Priority Academic Program Development of Jiangsu Higher Education Institutions
- National Science Foundation through the Science and Technology Center for Engineering Mechanobiology [CMMI 1548571]
- NIH [U01EB016422]
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Hydrostatic pressure (HP) regulates diverse cell behaviors including differentiation, migration, apoptosis, and proliferation. Abnormal HP is associated with pathologies including glaucoma and hypertensive fibrotic remodeling. In this review, recent advances in quantifying and predicting how cells respond to HP across several tissue systems are presented, including tissues of the brain, eye, vasculature and bladder, as well as articular cartilage. Finally, some promising directions on the study of cell behaviors regulated by HP are proposed.
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