Journal
ANTIOXIDANTS & REDOX SIGNALING
Volume 31, Issue 10, Pages 687-709Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2018.7674
Keywords
NADPH oxidases; metabolic disease; obesity; diabetes; ROS
Funding
- NIH [R01HL112914, R01HL079207, P01HL103455, T32 GM008424, T32 HL007563, DK114012]
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Recent Advances: The primary goal of this review is to highlight recent advances and survey our present understanding of cell-specific NOX enzyme contributions to metabolic diseases. Critical Issues: However, due to the short half-lives of individual ROS and/or cellular defense systems, radii of ROS diffusion are commonly short, often restricting redox signaling and oxidant stress to localized events. Thus, special emphasis should be placed on cell type and subcellular location of NOX enzymes to better understand their role in the pathophysiology of metabolic diseases. Future Directions: We discuss the targeting of NOX enzymes as potential therapy and bring to light potential emerging areas of NOX research, microparticles and epigenetics, in the context of metabolic disease.
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