Journal
BIOMATERIALS
Volume 41, Issue -, Pages 132-140Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2014.10.075
Keywords
PEDOT; Photothermal therapy; Photodynamic therapy; Pathogenic bacteria; NIR II window
Funding
- National Natural Science Foundation of China [21301121, 21273153, 21373268]
- Scientific Research Base Development Program of the Beijing Municipal Commission of Education [KM201410028008]
- Beijing Municipal Science & Technology Commission [Z131103002813097]
- Project of Construction of Innovative Teams and Teacher Career Development for Universities and Colleges under Beijing Municipality [IDHT20140512]
- Beijing Natural Science Foundation [2132008]
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PEDOT nanoparticles with a suitable nanosize of 17.2 nm, broad adsorption from 700 to 1250 nm, and photothermal conversion efficiency (eta) of 71.1%, were synthesized using an environmentally friendly hydrothermal method. Due to the electrostatic attraction between indocyanine green (ICG) and PEDOT, the stability of ICG in aqueous solution was effectively improved. The PEDOT nanoparticles modified with glutaraldehyde (GTA) targeted bacteria directly, and MU experiments demonstrated the low toxicity of PEDOT:ICG@PEG-GTA in different bacteria and cells. Pathogenic bacteria were effectively killed by photodynamic therapy (PDT) and photothermal therapy (PTF) with PEDOT:ICG@PEG-GTA in the presence of near-infrared (NIR) irradiation (808 nm for PDT, and 1064 nm for PTT). The combination of the two different bacteriostatic methods was significantly more effective than PTT or PDT alone. The obtained PEDOT:ICG@PEG-GTA may be used as a novel synergistic agent in combination photodynamic and photothermal therapy to inactivate pathogenic bacteria in both the NIR I and II window. (C) 2014 Elsevier Ltd. All rights reserved.
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