Journal
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 35
Volume 35, Issue -, Pages 191-211Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-cellbio-100617-062542
Keywords
crowding; systems biology; protein structure; molecular dynamics simulation; network models
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Comprehensive data about the composition and structure of cellular components have enabled the construction of quantitative whole-cell models. While kinetic network-type models have been established, it is also becoming possible to build physical, molecular-level models of cellular environments. This review outlines challenges in constructing and simulating such models and discusses near- and long-term opportunities for developing physical whole-cell models that can connect molecular structure with biological function.
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