Journal
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 35
Volume 35, Issue -, Pages 453-475Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-cellbio-100818-125300
Keywords
autophagosome; selective autophagy; mitophagy; ER-phagy; nutrient starvation
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Macroautophagy is an intracellular degradation system that delivers diverse cytoplasmic materials to lysosomes via autophagosomes. Recent advances have enabled identification of several selective autophagy substrates and receptors, greatly expanding our understanding of the cellular functions of autophagy. In this review, we describe the diverse cellular functions of macroautophagy, including its essential contribution to metabolic adaptation and cellular homeostasis. We also discuss emerging findings on the mechanisms and functions of various types of selective autophagy.
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