Journal
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Volume 1456, Issue 1, Pages 5-25Publisher
WILEY
DOI: 10.1111/nyas.14094
Keywords
adhesion G protein-coupled receptor; structural biology; signal transduction; mechanosensation; development; neurobiology; immunology; cancer
Categories
Funding
- Oregon Health & Science University (OHSU)
- Vollum Institute at OHSU
- University of Illinois at Chicago
- Rudolf Schonheimer Institute of Biochemistry
- Tecniplast
- Union Biometrica
- Zeiss
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [ZIAAA000284] Funding Source: NIH RePORTER
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The adhesion class of G protein-coupled receptors (GPCRs) is the second largest family of GPCRs (33 members in humans). Adhesion GPCRs (aGPCRs) are defined by a large extracellular N-terminal region that is linked to a C-terminal seven transmembrane (7TM) domain via a GPCR-autoproteolysis inducing (GAIN) domain containing a GPCR proteolytic site (GPS). Most aGPCRs undergo autoproteolysis at the GPS motif, but the cleaved fragments stay closely associated, with the N-terminal fragment (NTF) bound to the 7TM of the C-terminal fragment (CTF). The NTFs of most aGPCRs contain domains known to be involved in cell-cell adhesion, while the CTFs are involved in classical G protein signaling, as well as other intracellular signaling. In this workshop report, we review the most recent findings on the biology, signaling mechanisms, and physiological functions of aGPCRs.
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