Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 34, Pages 11836-11840Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201906665
Keywords
cycloalkenes; electrocyclic reactions; medium-sized rings; planar chirality; synthetic methods
Categories
Funding
- Japan Agency for Medical Research and Development Funding Source: Medline
- Japan Society for the Promotion of Science [JP19H03350, JP 16H05073, JP17J10201] Funding Source: Medline
- Ministry of Education, Culture, Sports, Science and Technology [JP18H04406, JP16H01147] Funding Source: Medline
- Tokyo Kasei Chemical Promotion Foundation Funding Source: Medline
Ask authors/readers for more resources
Development of a novel synthetic method for medium-sized trans-cycloalkenes (TCAs) is described. Functionalized TCAs are readily prepared from simple cycloalkanones in a few steps, namely, enol silyl ether formation, [2+2] cycloaddition, and domino 4 pi electrocyclic ring opening/alkylation (conjugate addition). The first example of central-to-planar chirality transfer from enantiomerically enriched cyclobutenes to TCAs is also described.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
