Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 34, Pages 11691-11694Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201905007
Keywords
biosensors; electrochemiluminescence; gold nanoclusters; quantum yield
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Funding
- National Natural Science Foundation of China [21675024, 21874020]
- Program for Innovative Leading Talents in Fujian Province [2016B016]
- Fujian Province Health Commission Young and Middle-Aged Talent training project [2018-ZQN-62]
- Program for Fujian Top-notch Innovative Personnel
- Natural Sciences and Engineering Research Council of Canada (NSERC)
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Gold nanoclusters (AuNCs) are attractive electrochemiluminescence (ECL) emitters because of their excellent stability, near IR emission, and biocompatibility. However, their ECL quantum yield is relatively low, and our limited fundamental understanding has hindered rational improvement of this parameter. Herein, we report drastic enhancement of the ECL of ligand-stabilized AuNCs by on-electrode pre-oxidation with triethylamine (TEA) as a co-reactant. The l-methionine-stabilized AuNCs resulted in a record high ECL yield of 66 %. This strategy was successfully extended to other AuNCs, and it is more effective for ligand shells that allow more effective electron transfer. In addition, excitation of the pre-oxidized ECL required a lower potential than conventional methods, and no additional instrument was required. This work opens avenues for solving a challenging problem of AuNC-based ECL probes and enriches fundamental understanding, greatly broadening their potential applications.
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