Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 35, Pages 12117-12122Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201906380
Keywords
nanoparticles; photodynamic therapy; upconversion nanoparticles
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Funding
- National Natural Science Foundation of China [21635005, 21827812, 21890741, 21605083]
- National Research Foundation for Thousand Youth Talents Plan of China
- Natural Science Foundation of Jiangsu Province [BK 20160644]
- State Key Laboratory of Analytical Chemistry for Life Science [5431ZZXM1806]
- Specially-appointed Professor Foundation of Jiangsu Province
- Program for Innovative Talents and Entrepreneurs of Jiangsu Province
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Despite the successful application of upconversion nanoparticles (UCNPs), their low energy transfer efficiency is still a bottleneck to further applications. Here we design UCNPs with a multilayer structure, including an inert NaYF4:Gd core and an energy-concentrating zone (ECZ), for efficient energy concentration. The ECZ is composed of an emitting layer of NaYF4:Yb,Er and an absorption layer of NaYF4:Nd,Yb with antenna IRDye 800CW to manipulate the energy transfer. The stable and tight packing of 800CW linked originally with a bisphosphonate ligand improves greatly the transfer efficiency. The proximity of the emitting layer to both surface antenna and accepter also decreases energy depletion. Compared to classical UCNPs, the ECZ UCNPs show 3600 times higher luminescence intensity with an energy transfer efficiency near 60 %. In proof-of-concept applications, this type of structure was employed for Hg2+ detection and for photodynamic therapy under hypoxic conditions.
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