Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 40, Pages 14055-14064Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201905532
Keywords
atom efficiency; carbonyl addition; enantioselectivity; hydrogenation; total synthesis
Categories
Funding
- Welch Foundation [F-0038]
- NIH [R01 GM093905]
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Use of abundant feedstock pronucleophiles in catalytic carbonyl reductive coupling enhances efficiency in target-oriented synthesis. For such reactions, equally inexpensive reductants are desired or, ideally, corresponding hydrogen autotransfer processes may be enacted wherein alcohols serve dually as reductant and carbonyl proelectrophile. As described in this Minireview, these concepts allow reactions that traditionally require preformed organometallic reagents to be conducted catalytically in a byproduct-free manner from inexpensive pi-unsaturated precursors.
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