Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 32, Pages 11001-11006Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201905643
Keywords
fluorescence; imaging agents; metastasis; nanostructures; peptides
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Funding
- Ministry of Science and Technology of China [2016YFA0101503, 2017YFA0205503] Funding Source: Medline
- the National Natural Science Foundation of China [21671198,21425103,21501192,21703282] Funding Source: Medline
- the Natural Science Foundation of Jiangsu Province [BK20170066, BE2016682] Funding Source: Medline
- the Open Research Fund Program of the State Key Laboratory of Virology of China [2016IOV004] Funding Source: Medline
- the Strategic Priority Research Program of Chinese Academy of Science [XDB32030200] Funding Source: Medline
- Youth Innovation Promotion Association of Chinese Academy of Sciences Funding Source: Medline
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Fluorescence-guided cytoreductive surgery is one of the most promising approaches for facile elimination of tumors in situ, thereby improving prognosis. Reported herein is a simple strategy to construct a novel chainlike NIR-II nanoprobe (APP-Ag2S-RGD) by self-assembly of an amphiphilic peptide (APP) into a nanochain with subsequent chemical crosslinking of NIR-II Ag2S QDs and the tumor-targeting RGD peptide. This probe exhibits higher capability for cancer cell detection compared with that of RGD-functionalized Ag2S QDs (Ag2S-RGD) at the same concentration. Upon intraperitoneal injection, superior tumor-to-normal tissue signal ratio is achieved and non-vascularized tiny tumor metastatic foci as small as about 0.2 mm in diameter could be facilely eliminated under NIR-II fluorescent imaging guidance. These results clearly indicate the potential of this probe for fluorescence-guided tumor staging, preoperative diagnosis, and intraoperative navigation.
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