Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 31, Pages 10558-10562Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201905723
Keywords
amipurimycin; antibiotic; glycosylation; miharamycin; nucleoside
Categories
Funding
- National Key Research & Development Program of China [2018YFA0507602]
- National Natural Science Foundation of China [21432012, 21621002, 21372252]
- Strategic Priority Research Program of CAS [XDB20020000]
- K. C. Wong Education Foundation
Ask authors/readers for more resources
The structural puzzle of amipurimycin, a peptidyl nucleoside antibiotic, is solved by total synthesis and X-ray diffraction analysis, with the originally proposed configurations at C3 ' and C8 ' inverted and those at C6 ', C2 '', and C3 '' corrected. A similar structural revision of the relevant miharamycins is proposed via chemical transformations and then validated by X-ray diffraction analysis. The miharamycins bear an unusual trans-fused dioxabicyclo[4.3.0]nonane sugar scaffold, which was previously assigned as being in the cis configuration.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available