Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 38, Pages 13394-13399Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201907754
Keywords
aza-BODIPY; photoacoustic imaging; J-aggregation; lipid nanoparticles; self-assembly
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Funding
- NSERC
- TFRI
- CIHR
- CFI
- CRC
- Princess Margaret Cancer Foundation
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Organic building blocks are the centerpieces of one-for-all nanoparticle development. Herein, we report the synthesis of a novel aza-BODIPY-lipid building block and its self-assembly into a liposomal nanoparticle (BODIPYsome). We observed optically stable NIR J-aggregation within the BODIPYsome that is likely attributed to J-dimerization. BODIPYsomes with cholesterol showed enhanced colloidal stability while maintaining a high extinction coefficient (128 mm(-1) cm(-1)) and high fluorescence quenching (99.70 +/- 0.09 %), which enables photoacoustic (PA) properties from its intact structure and recovered NIR fluorescence properties when it is disrupted in cancer cells. Finally, its capabilities for optical imaging (PA/fluorescence) were observed in an orthotopic prostate tumor mouse model 24 h after intravenous administration. Overall, the BODIPYsome opens the door for engineering new building blocks in the design of optically stable biophotonic imaging agents.
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