Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 11, Pages 4216-4230Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201906793
Keywords
detection methods; fluorescent probes; imaging; reactive oxygen species; superoxide anion
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Funding
- National Natural Science Foundation of China [21535004, 91753111, 21675105]
- Key Research and Development Program of Shandong Province [2018YFJH0502]
- National Major Scientific and Technological Special Project for Significant New Drugs Development [2017ZX09301030004]
- Natural Science Foundation of Shandong Province of China [ZR2017ZC0225]
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The superoxide anion (O-2(.-)) is widely engaged in the regulation of cell functions and is thereby intimately associated with the onset and progression of many diseases. To ascertain the pathological roles of O-2(.-) in related diseases, developing effective methods for monitoring O-2(.-) in biological systems is essential. Fluorescence imaging is a powerful tool for monitoring bioactive molecules in cells and in vivo owing to its high sensitivity and high temporal-spatial resolution. Therefore, increasing numbers of fluorescent imaging probes have been constructed to monitor O-2(.-) inside live cells and small animals. In this minireview, we summarize the methods for design and application of O-2(.-)-responsive fluorescent probes. Moreover, we present the challenges for detecting O-2(.-) and suggestions for constructing new fluorescent probes that can indicate the production sites and concentration changes in O-2(.-) as well as O-2(.-)-associated active molecules in living cells and in vivo.
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