Journal
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
Volume 303, Issue 6, Pages 1735-1742Publisher
WILEY
DOI: 10.1002/ar.24186
Keywords
extracellular vesicles; exosomes; mesenchymal stem cells; regenerative medicine
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Funding
- NIGMS NIH HHS [P20 GM104937, P30 GM122732] Funding Source: Medline
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Mesenchymal stem cells (MSCs) are pluripotent progenitor cells with the capabilities of self-renewing, differentiating into multiple lineages, and achieving trophic effects during tissue repair. MSCs can secrete extracellular vesicles (EVs) including exosomes and microvesicles, which mediate their trophic effects on other cells. Carrying a variety of intracellular molecules of MSCs including lipids, proteins, RNA (mRNA and noncoding RNA), and DNA, EVs deliver them into other cells to regulate tissue regeneration process. The therapeutic effects of MSC-derived EVs have been observed in a number of animal disease models. In this review, we focus on the current state and future directions of MSC-derived EVs in regenerative medicine. Anat Rec, 2019. (c) 2019 Wiley Periodicals, Inc.
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