Journal
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
Volume 357, Issue 6, Pages 468-473Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.amjms.2019.03.004
Keywords
Obstructive sleep apnea; Hypertension; Salivary; Alpha-amylase; Cortisol
Categories
Funding
- National Natural Science Foundation of China [81570082, 81770084, 81700084]
Ask authors/readers for more resources
Background: We aimed to assess the association between salivary alpha-amylase and salivary cortisol, and obstructive sleep apnea (OSA) severity. Methods: Fifty-eight adults with suspected OSA were divided into the following 4 groups based on the apnea hypopnea index (AHI): control (AHI <5 events/hour), mild OSA (5 events/hour <= 15 events/hour), moderate OSA (15 events/hour <= 30 events/hour) and severe OSA (AHI >30 events/hour) groups. Salivary samples were collected after overnight polysomnography. Correlations between the salivary biomarkers and polysomnography parameters were analyzed. Results: Salivary alpha-amylase levels of the moderate and severe OSA groups were significantly higher than those of the control and mild OSA groups, and no association was found between salivary cortisol and OSA severity. The salivary alphaamylase levels were positively correlated with the AHI (r = 0.538; P < 0.01) and microarousal index (r = 0.541, P < 0.01), and negatively correlated with the lowest pulse oxygen saturation (r = -0.375, P < 0.01). Salivary cortisol levels were significantly higher in patients with hypertension than in those without hypertension (10.01 +/- 2.77 ng/mL vs. 5.52 +/- 1.90 ng/mL, P < 0.05), and the salivary alpha-amylase levels were highest in the OSA concomitant hypertension group (32.81 +/- 11.85 U/mL). Areas under the receiver operator characteristic analysis revealed that the cutoff values of salivary alpha-amylase for identifying moderate-severe OSA and OSA concomitant hypertension were 17.64 U/mL (sensitivity 85%, specificity 91%) and 25.35 U/mL (sensitivity 70%, specificity 94%), respectively. Conclusions: Salivary alpha-amylase is positively associated with the severity of OSA and OSA concomitant hypertension.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available