Journal
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
Volume 316, Issue 6, Pages H1439-H1446Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpheart.00139.2019
Keywords
coronary blood flow; hibernation; myocardial infarction; myocardial ischemia; reperfusion; stunning
Funding
- German Research Foundation [SFB 1116, B08]
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This opinionated article reviews current concepts of myocardial ischemia. Specifically, the historical background is briefly presented. Then, the prevailing paradigm of myocardial oxygen-supply-demand imbalance is criticized since demand is a virtual parameter that cannot be measured and data on measurements of myocardial blood flow and contractile function rather support matching between flow and function. Finally, a concept of myocardial ischemia that focusses on the reduction of coronary blood flow to below 8-10 mu l/g per heat with consequences for myocardial electrical, metabolic, contractile and morphological features is advocated.
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