Journal
AMERICAN JOURNAL OF PERINATOLOGY
Volume 37, Issue 1, Pages 8-13Publisher
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-0039-1694005
Keywords
aneuploidy screening; cell-free DNA; fetal fraction; adverse pregnancy outcomes; fetal growth restriction
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Objective To test the hypothesis that high fetal fraction (FF) on first trimester cell-free deoxyribonucleic acid (cfDNA) aneuploidy screening is associated with adverse perinatal outcomes. Study Design This is a single-institution retrospective cohort study of women who underwent cfDNA screening at <14 weeks' gestation and delivered a singleton infant between July 2016 and June 2018. Women with abnormal results were excluded. Women with high FF (>= 95th percentile) were compared with women with normal FF (5th-95th percentiles). Outcomes investigated were preterm birth, small for gestational age, and hypertensive disorders of pregnancy. Results A total of 2,033 women met inclusion criteria. The mean FF was 10.0%, and FF >16.5% was considered high ( n = 102). Women with high FF had a greater chance of delivering a small for gestational age infant
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