Journal
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
Volume 152, Issue 3, Pages 384-391Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/ajcp/aqz052
Keywords
PD-L1; MSI-high; Intestinal carcinoma; Histologic subtypes
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Funding
- NIH/NIDDK [5P30 DK058404-13]
- NIH/NCI [5P50 CA095103-13]
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Objectives: To investigate patterns of programmed death protein-1 (PD-L1) expression in microsatellite instability (MSI)-high intestinal carcinomas and correlate them with pathologic and molecular features. Methods: One hundred and fifteen MSI-high and 41 microsatellite stable carcinomas were included. Tumor sections were immunohistochemically labeled for PD-L1. The results were correlated with histologic subtypes, MSI, and BRAF status. Results: As expected, MSI status was associated with PD-L1 expression. Among 115 MSI-high tumor. PD-L1 expression was observed on tumor cells in 28 tumors and on tumor-associated inflammatory cells in 77 tumors. Medullary carcinoma demonstrated more frequent PD-L1 expression on tumor cells than mucinous and typical adenocarcinoma. PD-L1 expression was more frequent in medullary and typical adenocarcinoma than in mucinous adenocarcinoma based on combined positive scores. Tumors with more nucleotide shifts by PCR-based MSI testing were more likely to express PD-L1. Conclusions: Expression of PD-L1 is different among different histologic subtypes of MSI-high intestinal carcinomas.
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