Journal
AGEING RESEARCH REVIEWS
Volume 52, Issue -, Pages 53-63Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2019.04.004
Keywords
Primary cilium; Aging; Neural stem cells; Stem cell exhaustion; Neurodegenerative diseases; Glioblastoma
Categories
Funding
- Instituto de Salud Carlos III
- FEDER Funds [PI13/02277, CP16/00039, DTS16/084, PI16/01580]
- Diputacion Guipuzcoa
- Industry and Health Departments of the Basque Country
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Brain aging is characterized by a progressive loss of tissue integrity and function as a consequence of impaired homeostasis and regeneration capacities. The primary cilium is a highly conserved organelle that projects from the cell surface in a single copy in virtually all mammalian cell types including neural stem/progenitors cells and neurons. Increasing evidence in the last decade points out that primary cilium could be a relevant mediator of neural stem cell activity, neurogenesis, neuronal maturation and maintenance, and brain tumorigenesis. In this review, we summarize the current knowledge about primary cilia roles in these processes. There is currently sufficient background to propose that defective primary cilia contribute to age-related cognitive decline and brain tumor development due to their critical roles in cell cycle control and signaling transduction. This might have potential applications on therapy against age-associated brain diseases.
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