Journal
BIOMATERIALS
Volume 53, Issue -, Pages 370-378Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2015.02.085
Keywords
Polymeric micelles; Docetaxel; Breast cancer; Tumour targeting; Antitumour efficacy
Funding
- Cristal Therapeutics
Ask authors/readers for more resources
Treatment with chemotherapy such as docetaxel (DIX) is associated with significant toxicity and tumour recurrence. In this study, we developed DTX-entrapped core-cross-linked polymeric micelles (DTX-CCL-PMs, 66 nm size) by covalently conjugating DTX to CCL-PMs via a hydrolysable ester bond. The covalent conjugation allowed for sustained release of DTX under physiological conditions in vitro. In vivo, DTX-CCL-PMs demonstrated superior therapeutic efficacy in mice bearing MDA-MB-231 tumour xenografts as compared to the marketed formulation of DTX (Taxotere (R)). Strikingly, a single intravenous injection of DTX-CCL-PMs enabled complete regression of both small (similar to 150 mm(3)) and established (similar to 550 mm(3)) tumours, leading to 100% survival of the animals. These remarkable antitumour effects of DTX-CCL-PMs are attributed to its enhanced tumour accumulation and anti-stromal activity. Furthermore, DTX-CCL-PMs exhibited superior tolerability in healthy rats as compared to Taxotere. These preclinical data strongly support clinical translation of this novel nanomedicinal product for the treatment of cancer. (C) 2015 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available