Journal
ADVANCED MATERIALS
Volume 32, Issue 13, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201901081
Keywords
cancer therapy; gene delivery; nanoparticles; nucleic acid; targeted delivery
Categories
Funding
- National Institute for Health Research [R01CA228133, R01EB022148] Funding Source: Medline
- NCI NIH HHS [T32 CA130840, R01CA228133, T32 CA153952, R01 CA228133] Funding Source: Medline
- NIBIB NIH HHS [R01EB022148, R01 EB022148] Funding Source: Medline
- NIH HHS [R01CA228133, R01EB022148] Funding Source: Medline
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Nucleic acids are a promising type of therapeutic for the treatment of a wide range of conditions, including cancer, but they also pose many delivery challenges. For efficient and safe delivery to cancer cells, nucleic acids must generally be packaged into a vehicle, such as a nanoparticle, that will allow them to be taken up by the target cells and then released in the appropriate cellular compartment to function. As with other types of therapeutics, delivery vehicles for nucleic acids must also be designed to avoid unwanted side effects; thus, the ability of such carriers to target their cargo to cancer cells is crucial. Classes of nucleic acids, hurdles that must be overcome for effective intracellular delivery, types of nonviral nanomaterials used as delivery vehicles, and the different strategies that can be employed to target nucleic acid delivery specifically to tumor cells are discussed. Additonally, nanoparticle designs that facilitate multiplexed delivery of combinations of nucleic acids are reviewed.
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