Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 29, Issue 36, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201903279
Keywords
3D scaffolds; bone regeneration; cartilage repair; osteochondral tissue engineering; polymer fibers
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Funding
- National Natural Science Foundation of China [51873207, 51803006, 51833010, 81671785, 51673190, 51603204, 51673187, 51520105004]
- Science and Technology Development Program of Jilin Province [20190201068JC]
- Research Program for Young and Middle-Aged Teachers of Fujian Province [JT180039]
- National Key Research and Development Program of China [2016YFC1100701]
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Successful regeneration of weight-bearing bone defects and critical-sized cartilage defects remains a major challenge in clinical orthopedics. In the past decades, biodegradable polymer materials with biomimetic chemical and physical properties have been rapidly developed as ideal candidates for bone and cartilage tissue engineering scaffolds. Due to their unique advantages over other materials of high specific-surface areas, suitable mechanical strength, and tailorable characteristics, scaffolds made of polymer fibers have been increasingly used for the repair of bone and cartilage defects. This Review summarizes the preparation and compositions of polymer fibers, as well as their characteristics. More importantly, the applications of polymer fiber scaffolds with well-designed structures or unique properties in bone, cartilage, and osteochondral tissue engineering have been comprehensively highlighted. On the whole, such a comprehensive summary affords constructive suggestions for the development of polymer fiber scaffolds in bone and cartilage tissue engineering.
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