Journal
ACTA HAEMATOLOGICA
Volume 143, Issue 2, Pages 112-117Publisher
KARGER
DOI: 10.1159/000500315
Keywords
Tumor-associated macrophages; Leukemia-associated macrophages; Nurse-like cells; Polarization; Leukemic cell growth
Categories
Funding
- National Natural Science Foundation of China (NSFC) [81670104]
Ask authors/readers for more resources
In addition to intrinsic factors, leukemia cell growth is influenced by the surrounding nonhematopoietic cells in the leukemic microenvironment, including fibroblasts, mesenchymal stem cells, vascular cells, and various immune cells. Despite the fact that macrophages are an important component of human innate immunity, tumor-associated macrophages (TAMs) have long been considered as an accomplice promoting tumor growth and metastasis. TAMs are activated by an abnormal malignant microenvironment, polarizing into a specific phenotype and participating in tumor progression. TAMs that exist in the microenvironment of different types of leukemia are called leukemia-associated macrophages (LAMs), which are reported to be associated with the progression of leukemia. This review describes the role of LAMs in different leukemia subtypes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available