Journal
ACS NANO
Volume 13, Issue 8, Pages 9292-9297Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.9b03880
Keywords
peptide; catalysis; self-assembly; micelle; vesicle; ATH; enantioselective
Categories
Funding
- NIH [GM119634]
- CRDF [OISE-18-63891-0]
- Ralph E. Powe Junior Enhancement Award
- Nappi Family Award
- Alexander von Humboldt Foundation
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Self-assembly enables formation of incredibly diverse supramolecular structures with practically important functions from simple and inexpensive building blocks. Here, we show how a semirational, bottom-up approach to create emerging properties can be extended to a design of highly enantioselective catalytic nanoassemblies. The designed peptides comprising as few as two amino acid residues spontaneously self-assemble in the presence of metal ions to form supramolecular, vesicle-like nanoassemblies that promote transfer hydrogenation of ketones in an aqueous phase with excellent conversion rates and enantioselectivities (>90% ee).
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