Journal
ACS NANO
Volume 13, Issue 6, Pages 6372-6382Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.8b06032
Keywords
growth factor; coaxial electrospinning; layer-by-layer; controlled release; bone defects
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Funding
- Natural Science Foundation of China [51873157, 81800943, 81771051]
- Natural Science Foundation of Hubei Province of China [2018CFB497]
- Fundamental Research Funds for the Central Universities of China [2042017kf0063]
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The regeneration of bone tissue is regulated by both osteogenic and angiogenic growth factors which are expressed in a coordinated cascade of events. The aim of this study was to create a dual growth factor-release system that allows for time-controlled release to facilitate bone regeneration. We fabricated core-shell SF/PCL/PVA nanofibrous mats using coaxial electrospinning and layer-by-layer (LBL) techniques, where bone morphogenetic protein 2 (BMP2) was incorporated into the core of the nanofibers and connective tissue growth factor (CTGF) was attached onto the surface. Our study confirmed the sustained release of BMP2 and a rapid release of CTGF. Both in vitro and in vivo experiments demonstrated improvements in bone tissue recovery with the dual-drug release system. In vivo studies showed improvement in bone regeneration by 43% compared with single BMP2 release systems. Time-controlled release enabled by the core-shell nanofiber assembly provides a promising strategy to facilitate bone healing.
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