Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 11, Issue 31, Pages 28213-28220Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b09690
Keywords
peptide nanosheet; 2-dimensional materials; seeded supramolecular polymerization; pathway complexity; amyloid-inspired peptide
Funding
- Department of Science & Technology (DST, SERB project) [ECR/2016/000401]
- Department of Biotechnology [BT/PR22067/NNT/28/1163/2016]
- University Grants Commission (UGC), New Delhi [2121310082]
- INST fellowship
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Peptide 1 with an A beta 42 amyloid nucleating core and a photodimerizable 4-methylcoumarin moiety at its N terminus demonstrates the step-wise self-assembly in water to form nanoparticles, with eventual transformation into 1D nanofibers. Addition of gamma-cyclodextrin to 1 with subsequent irradiation with UV light at 320 nm resulted in morphological conversion to free-standing 2D nanosheets mediated by the host-guest interaction. Mechanical agitation of the 1D and 2D nanostructures led to seeds with narrow polydispersity indices, which by mediation of seeded supramolecular polymerization found seamless control over the dimensions of the nanostructures. Such structural and temporal control to differentiate the pathway was exploited to tune the mechanical strength of hierarchical hydrogel materials. Finally, the dimensional characteristics of the positively charged peptide fibers and sheets were envisaged as excellent exfoliating agents for inorganic hybrid materials, for example, MoS2.
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