Journal
CELLS
Volume 8, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/cells8050465
Keywords
Rho GTPases; Dbl-homology; guanosine diphosphate to guanosine triphosphate exchange factors; protein tyrosine kinases; signaling; evolution; phosphorylation; tyrosine; animal models
Categories
Funding
- Castilla-Leon Government [CSI049U16, CLC-2017-01]
- Spanish Ministry of Science, Innovation and Universities (MSIU) [SAF2015-64556-R, RTI2018-096481-B-I00]
- Worldwide Cancer Research [14-1248]
- Ramon Areces Foundation
- Spanish Association against Cancer [GC16173472GARC]
- Programa de Apoyo a Planes Estrategicos de Investigacion de Estructuras de Investigacion de Excelencia of the Ministry of Education of the Castilla-Leon Government [CLC-2017-01]
- MISIU [BES-2013-063573]
- European Regional Development Fund
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Vav proteins play roles as guanosine nucleotide exchange factors for Rho GTPases and signaling adaptors downstream of protein tyrosine kinases. The recent sequencing of the genomes of many species has revealed that this protein family originated in choanozoans, a group of unicellular organisms from which animal metazoans are believed to have originated from. Since then, the Vav family underwent expansions and reductions in its members during the evolutionary transitions that originated the agnates, chondrichthyes, some teleost fish, and some neoaves. Exotic members of the family harboring atypical structural domains can be also found in some invertebrate species. In this review, we will provide a phylogenetic perspective of the evolution of the Vav family. We will also pay attention to the structure, signaling properties, regulatory layers, and functions of Vav proteins in both invertebrate and vertebrate species.
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