Journal
CELLS
Volume 8, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/cells8040379
Keywords
mitochondria; mtDNA; mitophagy; mtDNA distribution; mitochondrial dynamics
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Funding
- National Natural Science Foundation of China [31671393, 91854107]
- Fundamental Research Funds for the Central Universities [2042017kf0197, 2042017kf0242]
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Mitochondrion harbors its own DNA (mtDNA), which encodes many critical proteins for the assembly and activity of mitochondrial respiratory complexes. mtDNA is packed by many proteins to form a nucleoid that uniformly distributes within the mitochondrial matrix, which is essential for mitochondrial functions. Defects or mutations of mtDNA result in a range of diseases. Damaged mtDNA could be eliminated by mitophagy, and all paternal mtDNA are degraded by endonuclease G or mitophagy during fertilization. In this review, we describe the role and mechanism of mtDNA distribution and elimination. In particular, we focus on the regulation of paternal mtDNA elimination in the process of fertilization.
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