Related references
Note: Only part of the references are listed.Increased Serine and One-Carbon Pathway Metabolism by PKCλ/l Deficiency Promotes Neuroendocrine Prostate Cancer
Miguel Reina-Campos et al.
CANCER CELL (2019)
Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer
Christopher J. Halbrook et al.
CELL METABOLISM (2019)
Direct stimulation of NADP+ synthesis through Akt-mediated phosphorylation of NAD kinase
Gerta Hoxhaj et al.
SCIENCE (2019)
Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells
Martina Bajzikova et al.
CELL METABOLISM (2019)
Revisiting the role of dihydroorotate dehydrogenase as a therapeutic target for cancer
Joseph T. Madak et al.
PHARMACOLOGY & THERAPEUTICS (2019)
Molecular logic of mTORC1 signalling as a metabolic rheostat
Alexander J. Valvezan et al.
NATURE METABOLISM (2019)
Conversion of PRPS Hexamer to Monomer by AMPK-Mediated Phosphorylation Inhibits Nucleotide Synthesis in Response to Energy Stress
Xu Qian et al.
CANCER DISCOVERY (2018)
Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers
Fang Huang et al.
CELL METABOLISM (2018)
NUFIP1 is a ribosome receptor for starvation-induced ribophagy
Gregory A. Wyant et al.
SCIENCE (2018)
Small-Molecule Screen Identifies&IT De Novo&IT Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3
Karina N. Gonzalez Herrera et al.
CELL REPORTS (2018)
Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures
Joo Sang Lee et al.
CELL (2018)
Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth
Andrew G. Cox et al.
EMBO JOURNAL (2018)
Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis
Naiara Santana-Codina et al.
NATURE COMMUNICATIONS (2018)
mTOR signalling and cellular metabolism are mutual determinants in cancer
Dirk Mossmann et al.
NATURE REVIEWS CANCER (2018)
Dependence on the Pyrimidine Biosynthetic Enzyme DHODH Is a Synthetic Lethal Vulnerability in Mutant KRAS-Driven Cancers
Malvika Koundinya et al.
CELL CHEMICAL BIOLOGY (2018)
Phosphoribosyl Diphosphate (PRPP): Biosynthesis, Enzymology, Utilization, and Metabolic Significance
Bjarne Hove-Jensen et al.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2017)
CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells
Jiyeon Kim et al.
NATURE (2017)
Purine synthesis promotes maintenance of brain tumor initiating cells in glioma
Xiuxing Wang et al.
NATURE NEUROSCIENCE (2017)
Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC
Kiyotoshi Satoh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Twenty-five years of mTOR: Uncovering the link from nutrients to growth
David M. Sabatini
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
CHOLESTEROL SENSING Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex
Brian M. Castellano et al.
SCIENCE (2017)
A New View into the Regulation of Purine Metabolism: The Purinosome
Anthony M. Pedley et al.
TRENDS IN BIOCHEMICAL SCIENCES (2017)
PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition
Deepti Mathur et al.
CANCER DISCOVERY (2017)
Adaptive Reprogramming of De Novo Pyrimidine Synthesis Is a Metabolic Vulnerability in Triple-Negative Breast Cancer
Kristin K. Brown et al.
CANCER DISCOVERY (2017)
The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels
Gerta Hoxhaj et al.
CELL REPORTS (2017)
mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability
Alexander J. Valvezan et al.
CANCER CELL (2017)
mTORC1 signaling and the metabolic control of cell growth
Issam Ben-Sahra et al.
CURRENT OPINION IN CELL BIOLOGY (2017)
MYC Drives Progression of Small Cell Lung Cancer to a Variant Neuroendocrine Subtype with Vulnerability to Aurora Kinase Inhibition
Gurkan Mollaoglu et al.
CANCER CELL (2017)
Understanding the Intersections between Metabolism and Cancer Biology
Matthew G. Vander Heiden et al.
CELL (2017)
One-Carbon Metabolism in Health and Disease
Gregory S. Ducker et al.
CELL METABOLISM (2017)
Sequestration-Mediated Downregulation of de Novo Purine Biosynthesis by AMPK
Danielle L. Schmitt et al.
ACS CHEMICAL BIOLOGY (2016)
Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia
David B. Sykes et al.
CELL (2016)
Drug target molecules to guide immunosuppression
Stein Bergan et al.
CLINICAL BIOCHEMISTRY (2016)
NAD+ Kinase as a Therapeutic Target in Cancer
Philip M. Tedeschi et al.
CLINICAL CANCER RESEARCH (2016)
LKB1 loss links serine metabolism to DNA methylation and tumorigenesis
Filippos Kottakis et al.
NATURE (2016)
Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth
Andrew G. Cox et al.
NATURE CELL BIOLOGY (2016)
Spatial colocalization and functional link of purinosomes with mitochondria
Jarrod B. French et al.
SCIENCE (2016)
mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle
Issam Ben-Sahra et al.
SCIENCE (2016)
The Ras/Raf/MEK/ERK signaling pathway and its role in the occurrence and development of HCC
Lei Li et al.
ONCOLOGY LETTERS (2016)
Lysosomal recruitment of TSC2 is a universal response to cellular stress
Constantinos Demetriades et al.
NATURE COMMUNICATIONS (2016)
Fundamentals of cancer metabolism
Ralph J. DeBerardinis et al.
SCIENCE ADVANCES (2016)
The Redox Status of Cancer Cells Supports Mechanisms behind the Warburg Effect
Jorgelindo da Veiga Moreira et al.
METABOLITES (2016)
Tumor suppressor p53 and its mutants in cancer metabolism
Juan Liu et al.
CANCER LETTERS (2015)
Pyruvate Kinase Isoform Expression Alters Nucleotide Synthesis to Impact Cell Proliferation
Sophia Y. Lunt et al.
MOLECULAR CELL (2015)
Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis
Shiran Rabinovich et al.
NATURE (2015)
Regulation of mammalian nucleotide metabolism and biosynthesis
Andrew N. Lane et al.
NUCLEIC ACIDS RESEARCH (2015)
Regulation of mTORC1 by PI3K signaling
Christian C. Dibble et al.
TRENDS IN CELL BIOLOGY (2015)
YAP and TAZ: a nexus for Hippo signaling and beyond
Carsten Gram Hansen et al.
TRENDS IN CELL BIOLOGY (2015)
Regulation of nucleotide metabolism by mutant p53 contributes to its gain-of-function activities
Madhusudhan Kollareddy et al.
NATURE COMMUNICATIONS (2015)
ATM Couples Replication Stress and Metabolic Reprogramming during Cellular Senescence
Katherine M. Aird et al.
CELL REPORTS (2015)
Ribose-5-phosphate isomerase A regulates hepatocarcinogenesis via PP2A and ERK signaling
Shih-Ci Ciou et al.
INTERNATIONAL JOURNAL OF CANCER (2015)
Rheb Protein Binds CAD (Carbamoyl-phosphate Synthetase 2, Aspartate Transcarbamoylase, and Dihydroorotase) Protein in a GTP-and Effector Domain-dependent Manner and Influences Its Cellular Localization and Carbamoyl-phosphate Synthetase (CPSase) Activity
Tatsuhiro Sato et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Protein and Nucleotide Biosynthesis Are Coupled by a Single Rate-Limiting Enzyme, PRPS2, to Drive Cancer
John T. Cunningham et al.
CELL (2014)
Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome
Suchithra Menon et al.
CELL (2014)
Akt Phosphorylation and Regulation of Transketolase Is a Nodal Point for Amino Acid Control of Purine Synthesis
Arindam Saha et al.
MOLECULAR CELL (2014)
SAICAR Induces Protein Kinase Activity of PKM2 that Is Necessary for Sustained Proliferative Signaling of Cancer Cells
Kirstie E. Keller et al.
MOLECULAR CELL (2014)
THE BIOLOGY OF YAP/TAZ: HIPPO SIGNALING AND BEYOND
Stefano Piccolo et al.
PHYSIOLOGICAL REVIEWS (2014)
p90RSKS mediate the activation of ribosomal RNA synthesis by the hypertrophic agonist phenylephrine in adult cardiomyocytes
Ze Zhang et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2013)
Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1
Issam Ben-Sahra et al.
SCIENCE (2013)
Quantitative Phosphoproteomics Reveal mTORC1 Activates de Novo Pyrimidine Synthesis
Aaron M. Robitaille et al.
SCIENCE (2013)
Association of CAD, a multifunctional protein involved in pyrimidine synthesis, with mLST8, a component of the mTOR complexes
Akio Nakashima et al.
JOURNAL OF BIOMEDICAL SCIENCE (2013)
DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells
Yuriko Saiki et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)
Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism
Haoqiang Ying et al.
CELL (2012)
Targeting the PI3K pathway for cancer therapy
Navid Sadeghi et al.
FUTURE MEDICINAL CHEMISTRY (2012)
TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1
Christian C. Dibble et al.
MOLECULAR CELL (2012)
Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation
Jiangbin Ye et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation
Sophia Y. Lunt et al.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27 (2011)
GTP depletion synergizes the anti-proliferative activity of chemotherapeutic agents in a cell type-dependent manner
Tao Lin et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth
Daniela Gaglio et al.
MOLECULAR SYSTEMS BIOLOGY (2011)
DHODH modulates transcriptional elongation in the neural crest and melanoma
Richard Mark White et al.
NATURE (2011)
RAS oncogenes: weaving a tumorigenic web
Yuliya Pylayeva-Gupta et al.
NATURE REVIEWS CANCER (2011)
A Gene Expression Signature Associated with K-Ras Addiction Reveals Regulators of EMT and Tumor Cell Survival
Anurag Singh et al.
CANCER CELL (2009)
Enzymology of Purine and Pyrimidine Antimetabolites Used in the Treatment of Cancer
William B. Parker
CHEMICAL REVIEWS (2009)
Mizoribine: A New Approach in the Treatment of Renal Disease
Yukihiko Kawasaki
Clinical & Developmental Immunology (2009)
The molecular determinants of de novo nucleotide biosynthesis in cancer cells
Xuemei Tong et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2009)
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Matthew G. Vander Heiden et al.
SCIENCE (2009)
Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells
Sudha Mannava et al.
CELL CYCLE (2008)
Is cancer a disease of abnormal cellular metabolism? New angles on an old idea
Ralph J. DeBerardinis
GENETICS IN MEDICINE (2008)
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
Heather R. Christofk et al.
NATURE (2008)
Global Regulation of Nucleotide Biosynthetic Genes by c-Myc
Yen-Chun Liu et al.
PLOS ONE (2008)
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
David R. Wise et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
LKB1 modulates lung cancer differentiation and metastasis
Hongbin Ji et al.
NATURE (2007)
Protein kinase A phosphorylation of the multifunctional protein CAD antagonizes activation by the MAP kinase cascade
Damian H. Kotsis et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2007)
Protein kinase C modulates the up-regulation of the pyrimidine biosynthetic complex, CAD, by MAP kinase
Frederic D. Sigoillot et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2007)
Conditional transgenic models define how MYC initiates and maintains tumorigenesis
Constadina Arvanitis et al.
SEMINARS IN CANCER BIOLOGY (2006)
Chemotherapy in advanced gastric cancer: A systematic review and meta-analysis based on aggregate data
Anna D. Wagner et al.
JOURNAL OF CLINICAL ONCOLOGY (2006)
From methotrexate to pemetrexed and beyond. A review of the pharmacodynamic and clinical properties of antifolates
J Walling
INVESTIGATIONAL NEW DRUGS (2006)
Transcriptional regulation and transformation by MYC proteins
S Adhikary et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)
Mizoribine in combination therapy with tacrolimus for living donor renal transplantation: analysis of a nationwide study in Japan
T Akiyama et al.
TRANSPLANTATION PROCEEDINGS (2005)
Breakdown of the regulatory control of pyrimidine biosynthesis in human breast cancer cells
FD Sigoillot et al.
INTERNATIONAL JOURNAL OF CANCER (2004)
Severe impairment of nucleotide synthesis through inhibition of mitochondrial respiration
N Gattermann et al.
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS (2004)
ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth
J Zhao et al.
MOLECULAR CELL (2003)
The MYC Oncogene as a Cancer Drug Target
Heiko Hermeking
CURRENT CANCER DRUG TARGETS (2003)
Mutations of the BRAF gene in human cancer
H Davies et al.
NATURE (2002)
Growth-dependent regulation of mammalian pyrimidine biosynthesis by the protein kinase A and NLAPK signaling cascades
FD Sigoillot et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
The Raf/MEK/ERK pathway:: new concepts of activation
C Peyssonnaux et al.
BIOLOGY OF THE CELL (2001)
A review of dose-limiting events in phase I trials: antimetabolites show unpredictable relationships between dose and toxicity
L Seymour et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2001)
Basis for effective combination cancer chemotherapy with antimetabolites
GJ Peters et al.
PHARMACOLOGY & THERAPEUTICS (2000)
Regulation of carbamoyl phosphate synthetase by MAP kinase
LM Graves et al.
NATURE (2000)
Share Paper
