Journal
APPLIED BIOCHEMISTRY AND MICROBIOLOGY
Volume 52, Issue 5, Pages 476-482Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S0003683816050070
Keywords
anti-inflammatory effect; cytokines; chitosan; colitis; free radical depolymerization; myeloperoxidase
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Funding
- Russian Science Foundation [16-14-00051]
- Russian Science Foundation [16-14-00051] Funding Source: Russian Science Foundation
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A low-molecular derivative of the polysaccharide (5 kDa) was obtained and its cytokine-inducing and anti-inflammatory activity was studied by free radical depolymerization of chitosan (110 kDa). It was shown that high-molecular chitosan in vitro inhibited the synthesis of anti-inflammatory cytokine, the tumor necrosis factor alpha induced by endotoxin. In the case of peroral introduction to experimental animals, high- and low-molecular chitosans stimulated synthesis of the anti-inflammatory cytokine IL-10 in the blood serum of mice; in this case, the activity of the high-molecular derivative was two times higher as compared with the initial polysaccharide. With peroral introduction, the initial polysaccharide (50 mg/kg) and its derivative inhibited the development of chemically induced inflammation of experimental animals' large intestines, which was manifested as a decrease in the affected area and the degree of damage to the large intestine wall, as well as a two-fold reduction of myeloperoxidase activity. According to morphological and biochemical characteristics, the effect of chitosans was similar to that of a hormone anti-inflammatory drug, prednisolone.
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