Journal
CANCERS
Volume 11, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/cancers11040569
Keywords
glioblastoma multiforme; platelet; immune cell interaction; sphingosine-1-phosphate
Categories
Funding
- Gerhard-Domagk scholarship program
- Jung-Stiftung fur Wissenschaft and Forschung
- Forschungsverbund Molekulare Medizin
- Forschungsverbund Neurowissenschaften
Ask authors/readers for more resources
The link between thrombocytosis and malignancy has been well known for many years and its associations with worse outcomes have been reported mainly for solid tumors. Besides measuring platelet count, it has become popular to assess platelet function in the context of malignant diseases during the last decade. Malignant gliomas differ tremendously from malignancies outside the central nervous system because they virtually never form distant metastases. This review summarizes the current understanding of the platelet-immune cell communication and its potential role in glioma resistance and progression. Particularly, we focus on platelet-derived proinflammatory modulators, such as sphingosine-1-phosphate (S1P). The multifaceted interaction with immune cells puts the platelet into an interesting perspective regarding the recent advances in immunotherapeutic approaches in malignant glioma.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available