Journal
EBIOMEDICINE
Volume 43, Issue -, Pages 632-640Publisher
ELSEVIER
DOI: 10.1016/j.ebiom.2019.04.005
Keywords
Low protein intake; Low-protein/high-carbohydrate diet; Methionine; Branched-chain amino acids; Red meat; Longevity; Metabolic health
Funding
- Japan Society for the Promotion of Science [24591218]
- Grants-in-Aid for Scientific Research [24591218] Funding Source: KAKEN
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Lifespan and metabolic health are influenced by dietary nutrients. Recent studies show that a reduced protein intake or low-protein/high-carbohydrate diet plays a critical role in longevity/metabolic health. Additionally, specific amino acids (AAs), including methionine or branched-chain AAs (BCAAs), are associated with the regulation of lifespan/ageing and metabolism through multiple mechanisms. Therefore, methionine or BCAAs restriction may lead to the benefits on longevity/metabolic health. Moreover, epidemiological studies show that a high intake of animal protein, particularly red meat, which contains high levels of methionine and BCAAs, may be related to the promotion of age-related diseases. Therefore, a low animal protein diet, particularly a diet low in red meat, may provide health benefits. However, malnutrition, including sarcopenia/frailty due to inadequate protein intake, is harmful to longevity/metabolic health. Therefore, further study is necessary to elucidate the specific restriction levels of individual AAs that are most effective for longevity/metabolic health in humans. (c) 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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