Journal
CHEMISTRYSELECT
Volume 4, Issue 13, Pages 3636-3641Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201803227
Keywords
copper sulfide nanoparticles; drug loading; gene silencing; photothermal treatment; siRNA
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Funding
- National Key Research and Development Program [2016YFC0207101]
- National Natural Science Foundation of China [21403084, 61775080,11374127, 11304118, 81201738, 11674127]
- Major State Basic Research Development Program of China (973 Program) [2014CB643506]
- program of Chang Jiang Scholars and Innovative Research Team in University [IRT13018]
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A combination of treatment strategies with two or more different mechanisms can together prevent cancer progression. In this paper, we present a combination of strategies with siRNA interference-induced gene silencing, photothermal therapy and mesoporous drug delivery methods to cure cancer. First we synthesize oil-soluble copper sulfide nanoparticles, which are modified with mesoporous silica and (3-Aminopropyl)triethoxysilane (APTES), then use it as siRNA carrier to achieve siRNA transmission. At the same time, mesopores can also be used for drug delivery. Our results suggest that the copper sulfide nanomaterial loaded with siRNA and Adriamycin entered the cell successfully, and the composite can kill cancer cells effectively.
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